|
PNEUMOSTEM | 2011-01-01 Intratracheal Transplantation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Dose-Dependently Attenuates Hyperoxia-Induced Lung Injury in Neonatal Rats.
This study shows results that intratracheal transplantation of human UCB derived MSCs may attenuate hyperoxia-induced lung injury in neonatal rats by modulating host inflammatory responses and oxidative stress.· Issue information | Cell Transplant. 2011;20(11-12):1843-54. · Co-author | YS Chang, SJ Choi, DK Sung, SY Kim,W Oh, YS Yang, WS Park. |
|
Stem Cells | 2010-12-01 Irradiation enhances the tumor tropism and therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand-secreting human umbilical cord blood-derived mesenchymal stem cells in glioma therapy.
This study proved that when irradiation was added to brain tumor therapy, tumor tropism of hUCB-MSCs into which TRAIL gene inducing apoptosis was introduced was increased to enhance its therapeutic effect.· Issue information | Stem Cells. 2010 Dec;28(12):2217-28. · Co-author | Kim SM, Oh JH, Park SA, Ryu CH, Lim JY, Kim DS, Chang JW, Oh W, Jeun SS. |
|
Stem Cells | 2010-08-01 Galectin-3 secreted by human umbilical cord blood-derived mesenchymal stem cells reduces amyloid-beta42 neurotoxicity in vitro.
This study shows that galectin-3(GAL-3), a protein secreted from hUCB-MSCs, protects neurons from toxicity of amyloid-β, a cause substance of Alzheimer type dementia.· Issue information | FEBS Lett. 2010 Aug 20;584(16):3601-8. · Co-author | Kim JY, Kim DH, Kim DS, Kim JH, Jeong SY, Jeon HB, Lee EH, Yang YS, Oh W, Chang JW. |
|
Stem Cells | 2010-06-01 GD2 expression is closely associated with neuronal differentiation of human umbilical cord blood-derived mesenchymal stem cells.
Although GD-2 is known as a key factor to identify MSCs, this study shows that it plays a role to control neuronal differentiation of hUCB-MSCs.· Issue information | Cell Mol Life Sci. 2010 Jun;67(11):1845-58. · Co-author | Jin HJ, Nam HY, Bae YK, Kim SY, Im R, Yang YS, Oh WI, Choi SJ, Kim SW. |
|
Stem Cells | 2010-05-13 Microporation is a valuable transfection method for efficient gene delivery into human umbilical cord blood-derived mesenchymal stem cells.
This study reported that microporation technology can enhance efficiency of gene transfer therapy by introducing genes into MSCs efficiently, in using stem cell therapy.· Issue information | BMC Biotechnology 2010 10: 38-50. · Co-author | Lim JY, Park SH, Jeong CH, Oh JH, Kim SM, Ryu CH, Park SA, Ahn JG, Oh W, Jeun SS, Chang JW. |
|
Stem Cells | 2010-04-26 Application of human umbilical cord blood-derived mesenchymal stem cell in disease models.
This study explains that hUCB-MSC is a cell applicable to various diseases including cartilage injury, brain tumor, brain injury, pulmonary disease, and immune therapy as stem cell therapy.· Issue information | World J Stem Cells. Apr 26, 2010; 2(2): 34. 38. · Co-author | Kim JY, Jeon HB, Yang YS, Oh W, Chang JW. |
|
Stem Cells | 2009-04-01 Down-regulation of CD105 is associated with multi-lineage differentiation in human umbilical cord blood-derived mesenchymal stem cells.
This study identified that by controlling expression of CD105 known as a cell surface antigen, this antigen is associated with differentiation of hUCB-MSCs and suggested it as a cell marker that can measure differentiation state of hUCB-MSCs for the first time.· Issue information | Biochem Biophys Res Commun. 2009 Apr 17;381(4):676-81. · Co-author | Jin HJ, Park SK, Oh W, Yang YS, Kim SW, Choi SJ. |
|
Stem Cells | 2009-04-01 Overexpression of CXC chemokine receptors is required for the superior glioma- tracking property of umbilical cord blood-derived mesenchymal stem cells.
This study suggests that glioma cells secretes IL-8 and GRO-alpha and hUCB-MSCs expressing receptors to them, CXCR-1, 2, are effective in glioma therapy.· Issue information | Stem Cells Dev. 2009 Apr;18(3):511-9. · Co-author | Kim DS, Kim JH, Lee JK, Choi SJ, Kim JS, Jeun SS, Oh W, Yang YS, Chang JW. |
|
Stem Cells | 2008-12-01 Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
This study proves that hUCB-MSCs play a role as a useful delivery vehicle in gene transfer therapy against intracranial glioma.· Issue information | Cancer Res. 2008 Dec 1;68(23):9614-23. · Co-author | Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS. |
|
Stem Cells | 2008-08-01 Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways.
This study are results confirming signaling in neuronal differentiation of hUCB-MSCs by BDNF.· Issue information | J Neurosci Res. 2008 Aug 1;86(10):2168-78. · Co-author | Lim JY, Park SI, Oh JH, Kim SM, Jeong CH, Jun JA, Lee KS, Oh W, Lee JK, Jeun SS. |